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Semaglutide Semaglutide is a GLP-1 receptor agonist prescribed in an individualized compounded injection when clinically appropriate
Martinotti G, Reina D, Di Nicola M, Andreoli S, Tedeschi D, Ortolani I, Pozzi G, Iannoni E, D'Iddio S, Janiri L
compared the impact of single versus combined treatment with high-intensity interval exercise (HIIE) and GLP-1RA semaglutide on cognitive dysfunction in obese diabetic mice ( Altogether, these converging findings highlight the hybrid potential of exercise, GLP-1based therapies, and neuromodulation to optimize weight management, cognitive function, and metabolic health
It remains unclear whether these medications cause lasting gastroparesis, or whether they temporarily worsen gastric emptying in people who already had an underlying susceptibility
While liraglutide also showed cardiovascular benefit (13% reduction in the LEADER trial), semaglutides evidence is more recent, more robust, and specifically applicable to patients with obesity
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