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Lai et al., 2009
Although the current use of statins, cholesterol absorption inhibitors, and PCSK9 inhibitors has greatly increased the rate of LDL-C goal attainment, safe and effective lipid-lowering drugs are still needed
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Here we review receptor biology and coactivator coupling, the pharmacology of SLU-PP-332 in cells and animals, dosing paradigms and route considerations used in published studies, translational biomarkers and experimental endpoints, context-dependent risks and unknowns, and practical guidance for nonclinical study design
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