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Following the promising results of Bay 27-9955, several glucagon receptor antagonists have been developed however when administered over a longer period, have been met with several adverse effects including increased plasma alanine aminotransferase (ALT), LDL-cholesterol in addition to increased blood pressure and body weight (52)

However, taking Qsymia and Wegovy together is not generally recommended, as both medications are used for weight loss and combining them may increase the risk of side effects