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Nature 626 , 401410 (2024)
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Proteins were alkylated with 55 mM iodoacetamide for 20 min at RT in the dark and then digested overnight at 37 C using 0.02 g/ml trypsin
This suggests that Epitalon may not just restore telomere length through enzymatic activation, but it may actually reprogram the transcriptional readiness of cells, shifting their expression profiles toward a more youthful state
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