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The authors highlighted their stepwise approach to insulin reduction, which involved prompt weekly insulin dose decreases of 1020% when preprandial or fasting glucose levels were consistently between 80 and 130 mg/dL

Both components maintain stability in lyophilized form

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[4] A major double-blind study (17,604 participants) showed semaglutide (Wegovy) reduces major adverse cardiovascular events by 20% in adults with overweight/obesity and established cardiovascular disease, but without diabetes