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and therefore there is a coherent, well-motivated hypothesis not a conclusion that retatrutide would improve insulin resistance in many women with PCOS, most likely through weight- and hepatic-fat-mediated pathways

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So, for women who are following Hormone Replacement Therapy (HRT) by taking a pill, the decreased absorption of the drugs can actually cause a sudden (but unwanted) drop in estrogen causing mood swings and hot flashes to unexpectedly return