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Final Comments: This is the first Brazilian report of metabolic syndrome associated with SH2B1-related monogenic obesity successfully treated with sleeve gastrectomy
Both are E3 ubiquitin ligases that drive muscle protein breakdown (Sacheck et al., 2004)
10.1001/jamanetworkopen.2025.14857 100 PandeyA.PatelK
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They also support liver health, which is essential for effectively metabolizing fats
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