[2] [14] Conditions that impair intrinsic factor production such as pernicious anaemia or gastric surgery can lead to deficiency regardless of dietary intake
For research handling, the lyophilized powder should be stored at -20 C and protected from light
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When exposed to Ex-4, cell cycle analysis revealed an increase of cells in S (synthesis)-Phase [15, 16] and proliferation related markers ( cyclin D3 , cyclin-dependent kinase 4 ( CDK4 ), c-Myc and c-fos ) increased, while cell cycle inhibitors ( p21Cip1 and p27Kip1 ) were downregulated [16]
Plant-based eaters can become deficient over time, so supplementation (oral or injected) may be needed