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These could include symptoms such as itching, a rash/hives, swelling especially around the face or throat, or difficulty breathing
The results showed that mood improved and anxiety decreased at the 28mg/day dose.[ref] For patients with major depressive disorder, a study showed that the combination of curcumin (250mg) plus saffron (15mg/day) was effective in reducing depression scores, especially in people with atypical depression.[ref] In a comparison trial, saffron (30mg/day) was as effective as fluoxetine (Prozac) for mild to moderate depression after six weeks.[ref] Another study in adults with anxiety and depression looked at a 50mg saffron capsule taken twice a day
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The larger treatment effect reported by the authors of the Lixisenatide study (that manifested in trial participants younger than age 60), will need to be further investigated
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