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The MHRA has issued repeated safety alerts about the risks of purchasing unlicensed injectable peptides including GLP-1 receptor agonists and weight-loss injections from unregulated online sources, citing concerns about: Uncertain purity and potency of preparations not manufactured under GMP conditions Absence of validated stability data , including reconstituted shelf life and beyond-use dates Risk of microbial contamination in preparations made outside licensed aseptic facilities Mislabelling, adulteration, or counterfeit products sold through unregulated channels NICE guidance on pharmacotherapy for obesity currently covers licensed agents only

Diabetologia 60(8):14421453 Park S, Dong X, Fisher TL, Dunn S, Omer AK, Weir G et al (2006) Exendin-4 uses Irs2 signaling to mediate pancreatic beta cell growth and function

The doctor monitors tolerance and adjusts if needed

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