The NanoBiT tethering strategy and Nb35 were used to stabilize the protein complexes 35,36 (Supplementary Fig
Abbreviations CD: Crohns disease DPP-IV: Dipeptidyl peptidase IV DSS: Dextran sulfate sodium EEC: Enteroendocrine cells GI: Gastrointestinal tract GIP: Gastro-insulinotropic peptide GLP: Glucagon-like peptide GM-CSF: Granulocyte-macrophage colony-stimulating factor IBD: Inflammatory bowel diseases IFN-: Interferon IGF-1: Insulin-like growth factor 1 IL: Interleukin LPS: Lipopolysaccharide PC 1/3: Prohormone convertase 1/3 PEG: Polyethylene glycosyl SCFA: Short-chain fatty acids TNBS: 2,4,6-trinitrobenzenesulfonic acid TNF-: Tumor necrosis factor UC: Ulcerative colitis References Abrahami D, Douros A, Yin H, et al (2018) Dipeptidyl peptidase-4 inhibitors and incidence of inflammatory bowel disease among patients with type 2 diabetes: population based cohort study
A: Duration depends on proper storage conditions and aseptic technique
The study included more than 7,000 adults with type 2 diabetes (T2D) who initiated oral semaglutide treatment between April 1, 2021, and December 31, 2023
B cells produce antibodies to low-density lipoprotein (LDL), oxidized LDL, apolipoprotein B (ApoB), cellular debris, and even certain pathogens