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Mechanistically, we show that elevated flux of Gln-derived -ketoglutarate enhances HDAC5 expression and suppresses acetylation on histone 3 lysine residue 14 and lysine residue 56

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The tripeptide exists predominantly in the reduced (GSH) and oxidized (GSSG) forms, and the ratio between them (GSH:GSSG) is used as a marker to determine the presence of oxidative stress

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Frames were taken every 30 min over 24 h