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The addition of glucagon receptor agonism introduces some theoretical safety considerations not seen with GLP-1 agonists alone

doi: 10.23937/2378-3656/1410281 97 DesaiAPetrovJHashashJGPatelHBrahmbhattBKochharGSet al

Tirzepatide extreme appetite suppression can exacerbate disordered eating patterns and may be psychologically harmful for individuals with active eating disorders

They provide clear instructions on dosing, administration, and potential side effects, emphasizing the importance of reporting any unusual symptoms to the prescribing physician