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When studied together, they trigger a larger cellular response than the sum of their individual effects
Sitagliptin lowers blood sugar in two ways: It helps the body increase insulin to stabilize blood sugar and decrease sugar made in the liver
The absence of large controlled studies means this risk can't be quantified
Other examples include cystic fibrosis, where high levels of TGF-1 and myofibroblasts are present (98), alopecia areata where, on the contrary, a deficiency of dermal papillae fibroblasts' functions is observed (99), and amyotrophic lateral sclerosis characterised by abnormal perivascular fibroblast activity preceding the onset of the disease (100)
