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This treatment also led to activation of the ER stress pathway, as evidenced by increased PERK and eIF2 phosphorylation

Over 29 days of treatment, the peptide inhibited pulmonary artery muscularization (the thickening and stiffening of pulmonary arteries that drives this condition), prevented right heart hypertrophy (the enlargement of the right ventricle that occurs when it has to pump against increased resistance), and significantly decreased mortality

This randomized phase 2a #ClinicalTrial demonstrates that TPN171H, a potent and selective PDE5 inhibitor, significantly reduces pulmonary vascular resistance and improves acute hemodynamics in patients with #PulmonaryArterialHypertension (PAH), establishing it as a promising and well-tolerated oral therapeutic candidate for managing PAH