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The ADDF explicitly states: Little human evidence exists for potential side effects. Notably, Selank was removed from Category 2 in September 2024 when nominators withdrew the substance

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57 Positive effects of B12 on homocysteine levels have also been observed in other patient populations, including healthy adults, 46 vegetarian women, 58 generally healthy women, 59 older adults with elevated MMA and homocysteine, 37 and patients with type 2 diabetes mellitus

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The EFSA reviewed the safety question and agreed with United States that the UL be set at 1,000 g