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52 In a phase 1b trial done to evaluate the safety, pharmacokinetics and pharmacodynamics of orforglipron in patients with T2DM, orforglipron resulted in significant reductions in HbA1c, fasting blood glucose and body weight, with an adverse event profile consistent with that of other GLP-1RA
These medications are transforming obesity care, but we still dont have clear evidence on how they perform in people over 65, who often have different risks and vulnerabilities, says Kasia Lipska MD, MHS, associate professor of medicine (endocrinology), who is senior author of the study and Chens mentor
Investigation of the effect of oral metformin on dipeptidylpeptidase-4 (DPP-4) activity in Type 2 diabetes
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