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Design, synthesis and pharmacological evaluation of 4-(3-chloro-4-(3-cyclopropylthioureido)-2-fluorophenoxy)-7-methoxyquinoline-6-carboxamide (WXFL-152): a novel triple angiokinase inhibitor for cancer therapy
Cell 47, 349358
Unfortunately, present trial recruitment is mainly based on histologic grading and staging, and the response rates to investigational agents are often low
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