tirzepatide pancreas and Retatrutide for blood sugar control and weight loss Understanding Pancreatitis Risk with Mounjaro

Available evidence indicates that semaglutide reduces all-cause dementia rates when compared with placebo

It was approved by the US Food and Drug Administration in September 2019 for the treatment of adults with T2D and has since received approval from the European Medicines Agency

The ADA recommends fasting blood sugar below 95 mg/dL (5.3 mmol/L) and 1-hour post-meal blood sugar below 140 mg/dL (7.8 mmol/L)

Effects: * LDL cholesterol * Triglycerides * HDL cholesterol * Stabilizes atherosclerotic plaques * Reduces inflammation in blood vessels Indications * Hypercholesterolemia * Mixed dyslipidemia * Familial hypercholesterolemia * Prevention of: * Myocardial infarction * Stroke * Cardiovascular disease Used in patients with: * Diabetes mellitus * Hypertension * Atherosclerotic cardiovascular disease Dosage Typical adult dose: * 540 mg once daily Common starting doses: * 1020 mg daily * Lower doses in: * Elderly * Renal impairment * Asian patients Maximum: * 40 mg/day Pharmacokinetics * Oral administration * Long half-life (~19 hours) * Mainly hepatic action * Excreted partly unchanged in feces Adverse Effects Common * Headache * Myalgia * Abdominal pain * Nausea * Constipation Serious * Myopathy * Rhabdomyolysis * Hepatotoxicity * New-onset diabetes (rare) Monitoring Before and during therapy: * Lipid profile * Liver function tests * CK level if muscle symptoms occur Contraindications * Active liver disease * Pregnancy * Breastfeeding * Severe hypersensitivity Statins are contraindicated in pregnancy because cholesterol is important for fetal development

I spoke on the preclinical data of Amylin and its effect on appetite suppression