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For example, in 2014, a double-blind, randomized placebo-controlled trial published in JAMA followed a similar design, with patients randomized to tesamorelin (2 mg) or a placebo for six months

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Iveson T, Donehower RC, Davidenko I, Tjulandin S, Deptala A, Harrison M, et al

One study found that depleted levels of NAD+ had a "dramatic" drop in muscle strength and endurance, implying that NAD+ is a critical component in muscle function and recovery [7]

If you are taking it after drinking, many people find it helpful to take it right before bed or first thing in the morning with a full glass of water