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TRIUMPH-4, the first completed Phase 3 trial, showed 28.7% average body weight loss at 68 weeks on retatrutide 12mg versus 2.1% on placebo, as reported by Eli Lilly in December 2025 (peer-reviewed publication pending)
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The metabolic activation from glucagon receptor stimulation may increase evening alertness in some individuals
Washington (DC): National Academies Press (US)
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