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GI side effects were more common in the GLP-1RA groups with relative risks of 1.84 for diarrhea, 2.01 for nausea, 2.46 for vomiting, and 2.69 for constipation but these were generally mild and did not increase treatment discontinuation rates
They must be able to prove that they are prescribing off licence in the patients best interests
And if your current BMI means you dont qualify for standard GLP-1 doses, then rapid weight loss should not be your main goal
I will be posting an article on constipation hopefully later this year
At the starting dose of 0.25mg weekly, one vial provides 40 weekly doses, though reconstituted semaglutide should be used within 28 days for optimal potency
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