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Data shown that dysfunction of autophagy lysosome system can affect the clearance of A peptides and tau proteins, two major features of AD (74)

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Their rate of gastrointestinal side effects nearly doubled compared to the group that started at 2 mg and escalated (Jastreboff et al., NEJM 2023)

In this review, however, underexplored peptidereceptor systems are defined not by limited biological knowledge, but by a persistent mismatch between biological validation and pharmacologic exploitation