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To validate custom assays, patient-specific artificial chimeric curves were generated, diluting donor DNA into patients to reproduce the 50%, 10%, 1%, 0.1% and 0.01% donor chimerism situations
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Serjeant et al., 2018)
A purplish-red solid product was obtained
The complementary strengths of these systems may support a multi-stage RIRI therapeutic strategy integrating early localization, targeted delivery, and controllable activation, providing an intelligent treatment paradigm (Fig
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