tirzepatide and food noise may only temporarily suppress brain 'food noise' activity** *by Perelman School of Medicine at the University of Pennsylvania* A rare glimpse into the brain activity of a patient with obesity Brain activity associated with breakthrough

PlexusDx provides compounded semaglutide, tirzepatide, and GLP-Squared formulations from licensed 503A pharmaciesan alternative medication sourcerather than a telehealth membership model

Whilst paraesthesia is not listed as a recognised adverse reaction in UK product information, some patients report these sensations during treatment

Medications Some medications slow digestion, making food stay in the stomach longer, which can increase sulfur burps

As MC4R deficiency presents with severe obesity from childhood, trials of tirzepatide (NCT06439277 and NCT06075667) and other obesity medications in children and adolescents with obesity, including those with MC4R deficiency, are needed to provide the evidence base for earlier, and potentially chronic, treatment in genetically driven obesity

This can cause long-term digestive issues and may require additional procedures to repair