GH stimulates collagen synthesis, and some researchers report improved skin texture, hydration, and elasticity during this phase
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Scientific evidence for its effectiveness is limited
In animals, specifically DR in its various forms (CR/IF/STS, KD, protein restriction) has shown a potential for simultaneously targeting many of the pathways associated with insulin and IGF signaling, usually with no serious, or with even beneficial side effects such as a differential stress response between normal and tumor tissue
Further, it caused an increase in the activation of the Akt/GSK-3 pathway, indicating that IGF-1 could be a potential therapy for diabetic cardiomyocytes [9]