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It directly neutralizes reactive oxygen species (ROS) generated by the mitochondrial respiratory chain, regenerates oxidized vitamins C and E, and catalyzes the conjugation of xenobiotics via glutathione S-transferase (phase II detoxification)
No mutagenic, carcinogenic, or teratogenic effects were observed in the preclinical datasets published by the Zagreb group
doi:10.1590/S1516-89132013000500017 Ask M, Mapelli V, Hck H, Olsson L, Bettiga M (2013) Engineering glutathione biosynthesis of Saccharomyces cerevisiae increases robustness to inhibitors in pretreated lignocellulosic materials
A single MSC-based therapy can simultaneously enhance mitochondrial function, regulate redox signaling, modulate immunometabolic responses, and promote repair of the neurovascular unit
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