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As with any drug, GLP-1 side effects can range from mild to severe, and will vary from patient to patient

Everything else in this article (the protocol, the cadence, the post-care, the device pairing) is downstream of that single decision

Around week two, I noticed I was sleeping through the night without waking up from shoulder discomfort

In the 104-week STEP 5 trial, in adults with obesity or overweight with at least one weight-related comorbidity, along with diet and exercise, Wegovy pen delivered significant, sustained weight loss at 2 years 2 Analysis of all patients regardless of if they stayed on treatment Co-primary end point: Percent change in body weight 2 Percentage of patients achieving categorical weight loss at 2 years 2 *** Co-primary end point 5% weight loss: 77.1% Wegovy pen vs 34.4% placebo Confirmatory secondary end points 10% weight loss: 61.8% Wegovy pen vs 13.3% placebo 15% weight loss: 52.1% Wegovy pen vs 7% placebo Supportive secondary end point # ~1 out of 3 patients using the Wegovy pen achieved weight loss 36.1% of patients using the Wegovy pen vs 2.3% of patients taking placebo # Supportive secondary end points were not included in the statistical hierarchy and, as such, were not controlled for multiplicity

Canadian approval typically follows FDA decisions within six to twelve months