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Glutathione depletion caused by a range of chemicals leads to the up-regulation of c-jun and c-fos mRNA and enhances activator protein-1 (AP-1) DNA bind-ing activity (Kitteringham et al ., 2000)

Nature (2017) 544:1104

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Take Home Points Take Home Points PCOS is a highly complex and prevalent reproductive, endocrine, and metabolic disorder that needs to be detected and treated as early as possible to mitigate long-term complications Diet and physical activity should be the first line nutrition intervention for polycystic ovary syndrome (PCOS)

This is true for retinoids, acids, and copper peptides alike