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New England Journal of Medicine (2022) 4
Sapra KJ, Eisenberg ML, Kim S, Chen Z, Buck Louis GM
It has been used for centuries in traditional Chinese medicine, primarily as an antimicrobial for gut infections
And these medications are also originally for diabetes
But when doctors do prescribe them for overlapping metabolic issues (such as insulin resistance or obesity), the most commonly recommended medications include: Semaglutide (Ozempic/Wegovy) Tirzepatide (Mounjaro/Zepbound) technically a GLP-1 + GIP dual agonist Liraglutide (Saxenda) The choice depends on: How severe metabolic symptoms are Tolerance to side effects Cost and insurance status The clinicians expertise One study looking at GLP-1associated fat changes noted that visceral fat reduction can significantly improve inflammatory biomarkers, as shown in an adipose tissue study
