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They regulate energy metabolism, calcium homeostasis, signal transduction, and meiotic spindle formation

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Common side effects include: Oily or fatty stools Oily spotting on underwear Urgent bowel movements More frequent bowel movements Stomach pain or discomfort These side effects are more likely if you eat high-fat meals

Calculation of HOMA-IR index The homeostatic model assessment of insulin resistance (HOMA-IR) was calculated using the formula: HOMA-IR = [fasting insulin (mU/L) fasting glucose (mg/dL)/405] 75

For the fMRI group of WT mice, we used data from 11 WT mice recorded with an identical protocol from a previous, unpublished study