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Observed side effects in research settings are generally mild and may include temporary nausea-related observations, flushing-related observations, headache-related observations, fatigue-related observations, administration-site irritation, pigmentation variability, pigmentation variability involving freckles or moles, and temporary appetite-related response variability depending on research amount, UV exposure, administration frequency, skin type, and individual physiological sensitivity
It received GRAS (Generally Recognized as Safe) status for use as a food ingredient, which is a separate regulatory category
& den Ruijter, H
K., Farrar, J
(27) By improving mood and reducing mental stress, Lion's Mane can indirectly boost energy levels, making daily tasks feel less overwhelming and more manageable
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