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At the 10mg dose, tirzepatide achieves plasma concentrations that exceed the activation threshold for both receptors by substantial margins, roughly 10,000-fold above the EC50 for the GIP receptor and 250-fold above the EC50 for the GLP-1 receptor
Lancet Diabetes Endocrinol 9:653662
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Idf diabetes atlas: Global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045
Currently, it is widely used as a bioactive additive in the food industry, for example, in the processing of flour-based products, meat, fish, dairy products, and infant foods, and it is also extensively applied in the health supplement industry
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