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136, July 2015, pp

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The meta-analysis included 16 studies including patients with asymptomatic hyperuricemia and/or gout treated with febuxostat and were compared with placebo/allopurinol, demonstrating a significant reduction in renal events (doubling of serum creatinine concentration and/or entry into renal replacement therapy): HR 0.56, 95% CI 0.370.84, p = 0.006 and a slight decrease in the fall of glomerular filtration rate (0.90 ml/min/1.73 m2) and in albuminuria.49 Like the observed with allopurinol, there is currently insufficient evidence to suggest treatment with febuxostat for renal or cardiovascular protection in patients with asymptomatic hyperuricemia

[2] Keratin, produced by keratinocytes, an essential component of the skin The synthesis of glutathione, a powerful antioxidant As a precursor of cysteine, cystine is involved in metabolic pathways involving the synthesis of the antioxidant glutathione

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