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Guidance for industry: interim policy on compounding using bulk drug substances under section 503A of the Federal Food, Drug, and Cosmetic Act
Cardiovascular and hypoglycemic risk limit the use of sulfonylureas in T2DM, independent of asthma comorbidity, and a strong rationale for clinical benefit would need to be observed to warrant their further study in the asthma context
Notably, most ongoing clinical trials evaluating metformins role in AD prevention do not account for environmental contributors, such as chronic viral infections, despite increasing evidence of their involvement in AD pathology 46,47,48
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