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Many of these placebo-controlled studies have demonstrated that folic acid supplementation improved symptoms in severely depressed patients, elderly depressed and demented patients, and those with major acute depression or schizophrenia, particularly in individuals with RBC folate levels below 453 nmol/L (46)

The symptoms of vitamin B12 deficiency may be reversible in some cases and permanent in others

The ensuing phase is assigned tentatively as NADP + dissociation as formation of the thiolate-FAD absorption has been demonstrated to be contingent on dissociation of this product for the U597C enzyme

Two trials in acutely hospitalized patients have shown that short-term (around 7 days) vitamin C supplementation increased concentrations of ascorbic acid in plasma and leukocytes and led to 34-35% improvements in mood state, as measured by POMS (142, 143)

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