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Developed in the late 1990s/early 2000s as a focused hGH fragment, AOD-9604 was advanced into early clinical programs to investigate mechanism-driven metabolic effects and safety
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We first observed, in a previously published bulk RNA-seq dataset of MEFs undergoing in vitro reprogramming 40 , that Mtr and Cd320 were upregulated soon after OSKM induction, remaining high during the early and middle phases of reprogramming, ultimately stabilizing to levels above those measured in MEFs (Extended Data Fig
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