This side effect appears to be driven by multiple factors, including Mounjaros impact on the brain, reduced peripheral blood flow, decreased thermogenesis from lower food intake, and reduced insulation from weight loss
Common side effects Nausea Diarrhea Sweating Tremors Trouble sleeping Headache Fatigue Sexual side effects (low libido, difficulty reaching orgasm) Overdose symptoms Headache Drowsiness Blurred vision Fever Convulsions Slow or fast heart rate Coma Insomnia Nausea and vomiting Confusion Serious overdose symptoms Seizures Hallucinations Cardiovascular toxicity Suicidal thoughts Kidney failure Serotonin syndrome An SSRI overdose can trigger serotonin syndrome, a potentially fatal buildup of serotonin
When donating an electron, glutathione itself becomes reactive and readily reacts with another reactive glutathione to form GSSG
While heart palpitations are not listed as a common adverse reaction in FDA prescribing information, semaglutide can increase resting heart rate by 1-4 beats per minute, which some individuals may perceive as palpitations
Finally, its worth noting that aging itself disrupts circadian rhythms, but conversely, experimental circadian disruption (e.g., chronic jet-lag in animal models) can shorten lifespan and induce phenotypes of premature aging (Zhang et al., 2025)