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Cancer cell-derived exosomal circUSP7 induces CD8(+) T cell dysfunction and anti-PD1 resistance by regulating the miR-934/SHP2 axis in NSCLC

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15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25 Although inflammation is a powerful driver of tumor growth, 26 it is the aim of this review to focus on the connection between insulin/IGF-1 signaling and cancer, and discuss possibilities to modulate these interactions through DR and pharmaceutical interventions to improve cancer outcomes

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