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Most patients notice initial improvements within 2-4 weeks of starting peptide therapy, with significant changes typically occurring by 6-8 weeks
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Thus, in the course of aging various potentially pathogenic mechanisms, including the increase in oxidative damage, could on the one hand influence the quality of aging and on the other favour the onset and evolution of a definite neurodegenerative disease
Stabilization of the transition state in each reaction step may be provided by a conserved arginine that facilitates peptide bond formation
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