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It is known that the polar residues that reside within the TMD regulate biased signaling of the receptor (3), while the transmembrane helical boundaries and extracellular surface are a trigger for biased agonism (4)
Heterogeneous treatment effects of GLP-1RAs and SGLT2is on risk of Alzheimer's disease and related dementia in patients with type 2 diabetes: Insights from a real-world target trial emulation
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Spooner LM, Olin JL
A., Rees, K., Randeva, H
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