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Because tryptophan is an important carbon source, its extracellular degradation/ consumption imposes a metabolic challenge to both immune and tumor cells from the TME
Furthermore, their small size allows for easy synthesis and modification, facilitating their incorporation into drug-delivery systems or peptide-based therapeutics
Salt form confusion, sourcing concerns, and inconsistent quality have raised red flags
The diluent for any investigational peptide must always be the one specified in the trial protocol or product dossier
Fausto N, Laird AD, Webber EM: Liver regeneration
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