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Clinical trial data shows diarrhea rates of 19-23% across doses, with nausea remaining the predominant side effect at 24-31%

Previous data demonstrated that activation of GLP-1R could alleviate neuropathic pain, cancer pain and diabetic neuropathy [20]

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Despite its low potency at both receptors and less-certain in vivo activity at the GcgR, chronic OXM treatment decreased body weight and food intake in rodents when GLP-1R action was present [79,80,81]