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Conversely, conditions causing rapid gastric transit or malabsorption might theoretically affect drug uptake, though this is less well-documented given the subcutaneous route of administration for most GLP-1 therapies

263 Multiple clinical studies over the last few years have found that several GLP-1R agonists have beneficial effects on diabetic kidney disease independent of their glucose-lowering actions mediated by natriuresis, anti-inflammatory and anti-oxidative stress properties, and suppression of renal fibrosis

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