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The cardiovascular benefit is most consistent for the long-acting agents (liraglutide, injectable and oral semaglutide, and dulaglutide), whereas exendin-based and shorter-acting agents (lixisenatide, once-weekly exenatide) were largely neutral on MACE in dedicated outcomes trials [25]

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But the financial incentives point in one direction, and that direction is always toward more purchases

GLP1s reduce thirst and saliva production, and suppress appetite

Reta cramps are one of the most common complaints, with stomach cramps and stomach ache reports appearing across all active-dose groups in the NEJM Phase 2 trial