Many of the big papers including the often cited (Koeth et al, 2013) paper, and (Ling Ding et al, 2018), reported experimenters fed their mice amounts of TMAO or precursors that are 100x or more than what would be given in a supplement
Pregnancy and Birth Defects- It maintains folate levels during pregnancy and supports unborn development, reducing the risk of miscarriage and birth defects
Thats usually a conversation people have with their doctors, who know a lot about these medications and how they work. Even though it may seem like everyone on social media is talking about microdosing Ozempic, you shouldnt do it or adjust your dosage without consulting your healthcare provider first
Current guidelines do not recommend combination therapy with GLP-1 RAs and DPP-4 inhibitors, and the ADA/EASD consensus report specifically recommends discontinuation of DPP-4 inhibitors when initiating GLP-1 RA therapy
The decrease in gastric emptying that happens as a result of the GLP-1 medications can lead to food breaking down and fermenting in the stomach, causing malodorous burps and bad breath that can be noticeably unpleasant