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For semaglutide specifically, patients with kidney dysfunction do not require renal dosing adjustments (Key Considerations in Use of SGLT2 Inhibitors and GLP-1RAs for CV Risk Reduction in Patients with T2D, 2020) Contraindications to GLP-1 agonists include a history of serious hypersensitivity reactions to a GLP-1 agonist, pregnancy, breastfeeding, and a personal or family history of medullary or thyroid cancer or MEN2 (Key Considerations in Use of SGLT2 Inhibitors and GLP-1RAs for CV Risk Reduction in Patients with T2D, 2020)
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