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The resulting consensus provides an integrated synthesis of available evidence, incorporating data from RCTs, systematic reviews, meta-analyses, in vitro , and animal studies

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Furthermore, TNFAIP8 regulates ethanol-induced hepatic steatosis and confers HCC resistance to sorafenib and regorafenib [195]

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The structures were refined by combining manual adjustments in Coot v0.9.8.3 66 and ISOLDE 67 in UCSF ChimeraX 1.6.1 68 , followed by real-space refinement in PHENIX v1.20.1-4487 69 with Ramachandran, rotamer, torsion, and secondary structure restraints enforced

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