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GHK-Cu supplies the extracellular matrix remodeling via collagen, glycosaminoglycans and the MMP-TIMP system as well as an antioxidant and growth-factor-inducing component

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Its impact does not depend on testosterone, estrogen, progesterone, or thyroid levels

But, as with all medicine combinations, close clinical observation is needed to ensure that clozapine dosage and blood levels stay in target ranges, and that certain side effects potentials like gastric distress that might be compounded with the combination are well-managed