Considering the positive impact of Nrf2 in ameliorating oxidative stress, a number of bioactive components that exert protective effect against APAP-associated hepatotoxicity have been identified and reported, including caffeic acid that activates the Keap1-Nrf2 antioxidant defense system (Pang et al., 2016), carnosic acid that promotes nuclear translocation of Nrf2 (Guo et al., 2016), and esculentoside A that activates Nrf2 via AMP-activated kinase/Akt/glycogen synthase kinase 3 pathway (Wang et al., 2016)
But as scientists learn more about how cancer cells use glutamine, they hope to find other ways to selectively target cancers particular dependence while sparing normal cells
316 In KRAS/LKB1-mutant NSCLC, resistance to KRAS inhibitors such as adagrasib involves adeno-to-squamous transdifferentiation (AST), driven by Np63 and characterized by KRT6A expression
DOI: 10.1046/j.1460-9592.2003.t01-1-00262.x
I., de Martino, M., Lucca, I., Haitel, A., Shariat, S